‘Searching for sex differences’ – X-Y verschillen en de effecten op gezondheid
14 September 2020
15:31
Meer voor de prof dan de leek.
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It has been hypothesized that selection shaped sex differences in immune function in response to the evolution of pregnancy and the placenta in mammals, beginning more than 90 million years ago and contributing to the observed sex differences in diseases today, including a female bias in autoimmune disease and male bias in most cancers (9). Sex differences in gene expression are broadly shared across mammals, but their role in shaping sex differences in disease etiology has not been thoroughly explored. Oliva et al. report that genes that show differences between sexes are enriched for multiple pathways, including in immune responses and cancer.
