NEJM: ‘Hydroxychloroquine geen effectieve behandeling, kan juist zorgen voor extra risico’s’
11 October 2020
11:29
“The second study, by the Randomized Evaluation of COVID-19 Therapy (RECOVERY) Collaborative Group, compared hydroxychloroquine with usual care in 1,561 hospitalized adults with coronavirus. Participant enrollment began on Mar 25 and closed on Jun 5 after a preliminary analysis showed that hydroxychloroquine was ineffective.
Of the 1,561 patients randomly assigned to receive hydroxychloroquine, 421 (27.0%) died within 28 days, compared with 790 of the 3,155 patients (25.0%) assigned to usual care (rate ratio, 1.09). The authors said the study findings suggest that patients receiving hydroxychloroquine were less likely than those in the placebo group to be released from the hospital within 28 days (59.6% vs 62.9%; rate ratio, 0.90).
The authors concluded that hydroxychloroquine is not an effective treatment for hospitalized COVID-19 patients and that it could result in longer hospital stays and a higher risk of mechanical ventilation than usual care.”
