Experiment: menselijke transplantatie longen ‘inpluggen’ in varkens heeft helend effect
14 July 2020
10:19
Attaching Damaged Lungs to Pigs Can Heal Them, Experiment Shows
A new experimental technique shows how connecting the circulatory system of pigs to damaged human lungs can restore the latter to function, according to a recent paper published in the journal Nature Medicine.
Xenogeneic cross-circulation for extracorporeal recovery of injured human lungs
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Here we demonstrate that acutely injured human lungs declined for transplantation, including a lung that failed to recover on EVLP, can be recovered by cross-circulation of whole blood between explanted human lungs and a Yorkshire swine. This xenogeneic platform provided explanted human lungs a supportive, physiologic milieu and systemic regulation that resulted in functional and histological recovery after 24 h of normothermic support. Our findings suggest that cross-circulation can serve as a complementary approach to clinical EVLP to recover injured donor lungs that could not otherwise be utilized for transplantation, as well as a translational research platform for immunomodulation and advanced organ bioengineering.
